Onglyza (Saxagliptin) Medication


Onglyza (Saxagliptin)

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Table of contents:

Drug Description


Onglyza is a prescribed medication used alongside a proper diet and exercise to help regulate elevated blood sugar levels in individuals with type 2 diabetes—a condition characterized by insufficient insulin production or utilization in the body. 

As a dipeptidyl peptidase-4 (DPP-4) inhibitor, Onglyza elevates the levels of naturally occurring substances known as incretins. These incretins play a vital role in managing blood sugar by stimulating insulin release, particularly following meals, while also reducing the production of sugar by the liver. 

Uses and Dosage 

Before taking Onglyza and with each prescription refill, carefully review its medication guide and patient information leaflet. Ask your doctor or pharmacist if you have queries or concerns. 

The dosage of Onglyza is determined based on the patient’s medical condition, treatment response, and concurrent medications. 

Typically, this medication is taken once a day as prescribed by the doctor, without regard to food intake. The tablets must be swallowed whole and should not be cut or split. 

For optimal results, ensure to take Onglyza consistently and at a fixed time daily. Adhere strictly to the medication regimen, dietary plan, and exercise program prescribed by your doctor. 

Side Effects 

Listed below are the potential adverse effects of Onglyza. If any of them last or worsen, promptly notify your doctor. 

Common Side Effects 

  • Painful urination 
  • Headache 
  • Runny or stuffy nose 
  • Sore throat 
  • Cough 
  • Swelling in hands or feet 

Serious Side Effects 

  • Severe or persistent joint pain 
  • Pain or burning sensation during urination 
  • Heart-related symptoms: 
    • Shortness of breath (even at rest) 
    • Weakness or fatigue 
    • Rapid weight gain 
    • Swelling (particularly in the feet, legs, or midsection) 

Inform your doctor right away if any of the severe side effects above are experienced. 

Cease Onglyza usage immediately and promptly contact your healthcare provider if you experience indications of pancreatitis, such as: 

  • Intense upper abdominal pain radiating to the back 
  • Nausea 
  • Vomiting 
  • Loss of appetite 
  • Rapid heartbeat 

Allergic Reactions 

Although rare, a severe allergic reaction to Onglyza may occur. Seek immediate medical assistance if you observe any of the following symptoms: 

  • Hives 
  • Skin rash (purple or red) that spreads, blisters, and peels 
  • Breathing difficulty 
  • Swelling (face, lips, tongue, or throat) 

Not all side effects of Onglyza are included in this list. Notify your doctor promptly if any unlisted effects are observed. 


Before starting treatment with Onglyza, inform your doctor of any known allergies, particularly to saxagliptin, other drugs, or any of the components of Onglyza tablets. 

To ensure Onglyza is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Kidney disease 
  • Pancreatic disease (pancreatitis) 
  • Risk factors for pancreatitis (such as gallbladder stones, alcohol use/abuse, elevated blood lipid levels) 
  • Heart failure 

Regularly monitor your blood sugar levels and promptly inform your doctor of any high or low blood sugar symptoms. Your doctor may need to adjust your diabetes management plan accordingly. 

Inform your doctor and pharmacist about all prescription and non-prescription medications, vitamins, and herbal supplements you are currently taking, planning to take, or stop, as certain drugs may impact your blood sugar control.  

Certain medications can impact the elimination of Onglyza from the body, potentially influencing its effectiveness. Such medicines include: 

  • Azole antifungals (e.g., itraconazole, ketoconazole) 
  • HIV protease inhibitors (e.g., saquinavir) 
  • Nefazodone 
  • Telithromycin 
  • Ritonavir 

Managing blood sugar levels can be more challenging during periods of bodily stress (e.g., fever, infection, injury, or surgery). Consult your doctor, as such situations may necessitate modifications to your treatment plan, medications, or blood sugar testing routine. 

Onglyza is contraindicated for type 1 diabetes and diabetic ketoacidosis. 

Onglyza, along with other antidiabetic drugs, must only be administered during pregnancy when necessary. Discuss the risks and benefits of this medication with your doctor before use. 

Consult a healthcare professional before breastfeeding, as it is uncertain whether saxagliptin is excreted in breast milk. 

Additional information

Generic name:





2.5mg, 5mg

Quantities Available:

28, 30, 84, 90, 112

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Onglyza (Saxagliptin). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Onglyza (Saxagliptin).