Optimmune (Cyclosporine) Medication

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Generic Alternative - Optimmune (Cyclosporine)

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Optimmune is an ophthalmic medication for canines that can only be used by or on the order of a licensed veterinarian due to legal restrictions. 

This medication is indicated for the management of keratoconjunctivitis sicca (KCS – long-term dry eye) and chronic superficial keratitis (CSK – inflammatory conditions of the cornea) in dogs. 

Optimmune is thought to function as a local immunomodulator for immune-mediated conditions like KCS and CSK. The precise mechanism by which this medication enhances tear production in KCS management remains unclear. 

Uses and Dosage 

Before using Optimmune, and every time you get a refill, carefully review its medication guide and information leaflet. Ask your veterinarian if you have any questions or concerns. 

Optimmune is exclusively intended for canine ophthalmic application. 

Typically, this medication is applied to the dog’s affected eye(s) every 12 hours. 

To properly apply Optimmune, follow these steps: 

  1. Begin by clearing any debris on your dog’s eyes using appropriate nonirritating solutions. 
  2. Take a 1/4-inch strip of ointment. 
  3. Apply the ointment to the affected eye(s) either directly on the cornea or into the conjunctival sac. 

To effectively treat KCS, administer this ointment before any irreversible damage to the lacrimal tissue or dense corneal scarring or pigmentation occurs. 

Consult your veterinarian before ceasing the use of Optimmune. Abrupt cessation of the treatment can lead to a swift recurrence of symptoms, which might be mistakenly attributed to an adverse reaction to the ointment. 

Side Effects 

During clinical trials, a few treated dogs experienced the following side effects: 

  • Ocular and periocular inflammatory reactions  
  • Temporary redness 
  • Excessive tearing 
  • Slight eye discomfort 
  • Mild hair loss 

Notify your veterinarian promptly if any unlisted effects of Optimmune are observed. 


The impact of Optimmune on KCS in dogs has not been established for cases involving: 

  • Congenital alacrima 
  • Sulfonamide use 
  • Canine distemper virus 
  • Metabolic disorders 
  • Third eyelid gland removal 
  • Facial nerve paralysis causing palpebral reflex loss 

Results may not be immediate when transitioning from another treatment to Optimmune for KCS or CSK. It may take several days to a few weeks before the clinical effects of this medication are strong enough to discontinue previous therapy. 

The safety of Optimmune has not been established for preexisting viral or fungal ocular infections. Postponing Optimmune treatment until the fungal/viral ocular infection has been effectively treated is recommended. 

The safety of Optimmune has not been established in puppies, pregnant bitches, or breeding dogs. 

Additional information

Generic name:



Eye Ointment



Quantities Available:

5g, 10g

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Optimmune (Cyclosporine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Optimmune (Cyclosporine).