Vetoryl (Trilostane) Medication


Vetoryl (Trilostane)

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Drug Description


Vetoryl is a prescription drug intended exclusively for use by or under the supervision of a licensed veterinarian for managing pituitary-dependent and adrenal-dependent hyperadrenocorticism (Cushing’s disease) in canines. 

Hyperadrenocorticism is characterized by excessive cortisol hormone production, and Vetoryl, as an adrenocortical suppressant, works by reducing cortisol production in the adrenal glands to manage the symptoms of the said condition. 

Uses and Dosage 

Prior to administering Vetoryl to your dog, thoroughly review the prescription’s accompanying client information sheet provided by your veterinarian. 

Vetoryl is typically administered once daily with food as directed by the veterinarian. 

The initial treatment dose is typically set at the lowest possible level, determined by the dog’s weight. 

Following 10-14 days of administering the initial dose, the veterinarian will need to reassess your dog’s condition and conduct a test, paying close attention to electrolytes, renal function, and hepatic function. 

If the physical examination yields satisfactory results, the veterinarian can evaluate the need for treatment adjustment, which may include one of the following options: 

  • Cease treatment and restart at a lower dose. 
  • Maintain the same dose. 
  • Either continue with the current dose if clinical signs are well managed or increase the dose if symptoms of hyperadrenocorticism persist. 
  • In some cases, increasing the initial dose may also be considered. 

After finding the right Vetoryl dose for your dog, it is important to check their condition 30 days later, then at 90 days, and every 3 months after that. 

Side Effects 

Listed below are the potential adverse effects of Vetoryl. Inform your veterinarian promptly if any of them last or worsen. 

Common Side Effects 

  • Decreased appetite 
  • Vomiting 
  • Lethargy 
  • Diarrhea 
  • Weakness 

Serious Side Effects 

  • Severe depression 
  • Hemorrhagic diarrhea 
  • Collapse 
  • Hypo adrenocortical crisis 
  • Adrenal necrosis or rupture 

Dog owners must be advised to discontinue treatment with Vetorly and promptly inform their veterinarian if their dog experiences the above-listed adverse reactions. 

Not all side effects of Vetoryl are included in this list. Inform your veterinarian of any unlisted effects that may arise. 


Hypoadrenocorticism can occur at any Vetoryl dose, with adrenal function taking months to recover, and some dogs may never fully regain it. Therefore, a comprehensive history and physical examination are essential before starting Vetoryl therapy for all dogs. 

Vetoryl is contraindicated for the following: 

  • Dogs with a confirmed hypersensitivity to trilostane 
  • Animals with primary liver disease or renal insufficiency 
  • Pregnant dogs 

To minimize the risk of drug interactions with Vetoryl, provide your veterinarian with a comprehensive list of your dog’s medications, including over-the-counter products and dietary supplements. 

Exercise caution when using angiotensin-converting enzyme (ACE) inhibitors alongside Vetoryl, as both medications can lower aldosterone levels, potentially affecting electrolyte balance, blood volume, and renal function.  

Avoid combining Vetoryl with potassium-sparing diuretics like spironolactone, as both drugs can inhibit aldosterone, increasing the risk of hyperkalemia. 

Human Warnings: 

  • Keep Vetoryl out of reach of children as it is not for human use. 
  • After use, wash your hands thoroughly. 
  • Do not open or split capsules. 
  • Avoid handling capsules if pregnant or attempting to conceive due to potential teratogenic effects and early pregnancy loss observed in laboratory animals. 
  • In case of accidental ingestion or overdose, seek immediate medical advice and take the labeled container. 

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Vetoryl (Trilostane). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Vetoryl (Trilostane).