Procardia XL (Nifedipine XL) Medication


Procardia XL (Nifedipine XL)

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Table of contents:

Drug Description


Procardia XL is a prescription medicine indicated for the treatment of hypertension (high blood pressure). By reducing blood pressure, it helps lower the chances of fatal and nonfatal cardiovascular incidents, particularly strokes and heart attacks. 

This medication is also prescribed for select forms of angina, aiding in enhancing exercise capacity and reducing the frequency of chest pain episodes. However, it should not be utilized for immediate relief during chest pain occurrences. 

Classified as a calcium-channel blocker, Procardia XL reduces blood pressure by inducing relaxation in the blood vessels, alleviating the strain on the heart. It also effectively manages chest pain by enhancing the heart’s blood and oxygen supply. 

Uses and Dosage 

Before taking Procardia XL and with each prescription refill, carefully review its medication guide and patient information leaflet. If you have any inquiries, seek clarification from your doctor or pharmacist. 

Procardia XL dosage is determined according to individual medical conditions and treatment response.  

Your doctor will likely initiate this medication at a low dose and incrementally raise it, usually every 7 to 14 days. Strictly adhere to your doctor’s instructions. 

Procardia Xl is usually taken once daily, regardless of meals. Swallow the tablets whole and avoid biting or dividing them, as this may lead to the rapid release of the entire medication, heightening the chances of experiencing side effects. 

To achieve optimal outcomes, take this medication at a consistent time every day. Continue taking it even if you are feeling well, as most individuals with high blood pressure do not exhibit symptoms of illness. 

Consult your doctor before discontinuing Procardia XL, as abrupt cessation of this medication may worsen your condition. Gradually reducing your dose may be necessary. 

Side Effects 

Listed below are the potential adverse effects of Procardia XL. If any of them last or worsen, tell your doctor right away. 

Common Side Effects 

  • Swelling 
  • Flushing (warmth, redness, or tingling sensation) 
  • Headache or dizziness 
  • Nausea or heartburn 
  • Fatigue or weakness 

Serious Side Effects 

  • Aggravation of chest pain 
  • Pounding heartbeats or fluttering in the chest 
  • Feeling light-headed, with a risk of fainting 
  • Swelling in the hands or lower legs 
  • Upper stomach pain and jaundice (yellowing of the skin or eyes) 

Contact your doctor right away if you encounter any severe side effects. 

A severe skin reaction may also occur while taking Procardia XL. Seek immediate medical assistance if experiencing the following symptoms: 

  • Fever 
  • Sore throat 
  • Burning eyes 
  • Skin pain 
  • Red or purple skin rash with blistering and peeling 

Allergic Reactions 

Although rare, a severe allergic reaction to Procardia Xl may occur. Immediate medical assistance must be sought if any of the following signs of severe allergic reactions are noticed:  

  • Hives 
  • Difficult breathing 
  • Swelling (face, lips, tongue, or throat) 

Not all side effects of Procardia Xl are included in this list. Tell your doctor if any unlisted effects are observed. 


Before starting treatment with Procardia XL, inform your doctor if you have any known allergies, particularly to: 

  • Nifedipine xl  
  • Other calcium channel blockers (e.g., amlodipine, felodipine) 
  • Other medications 

Ask your pharmacist for more details, as Procardia XL may contain inactive components that may trigger allergic reactions or other complications. 

To ensure Procardia XL is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Heart diseases, such as congestive heart failure or aortic stenosis 
  • Liver problems 
  • Esophagus, stomach, or intestine problems, including narrowing/stricture, motility disorders, or obstruction 
  • Kidney problems 
  • Metabolic disorder called porphyria 

Ensure all your healthcare providers are informed of any current, newly started, or stopped medications, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements, to avoid potential drug interactions with Procardia XL. 

Some of the products that may interact with Procardia XL include: 

  • Alpha blockers like doxazosin 
  • Intravenous administration of calcium or magnesium sulfate 
  • Digoxin 
  • Fentanyl 
  • Melatonin 

The elimination of Procardia XL from the body can be influenced by other medications, potentially impacting its effectiveness. Examples of such medications include: 

  • Apalutamide 
  • Cimetidine 
  • Enzalutamide 
  • Mitotane 
  • Quinupristin/dalfopristin 
  • St. John’s wort 
  • Rifamycins (such as rifabutin, rifampin) 
  • Anticonvulsant drugs (such as carbamazepine, phenytoin) 

Certain products contain ingredients that may increase heart rate or blood pressure. 

Inform your pharmacist about the products you are using, and inquire about their safe usage, particularly for cough-and-cold remedies, diet aids, or non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen. 

Consult your doctor or pharmacist before consuming grapefruit or grapefruit juice while taking Procardia XL, as it may heighten the risk of experiencing side effects. 

Before surgery, inform the surgeon about your usage of Procardia XL. It may be necessary to discontinue this medication at least 36 hours before the surgical procedure. 

Procardia XL can cause dizziness. Consumption of alcohol or marijuana (cannabis) can intensify this effect. Limit alcohol intake and consult your doctor if using marijuana (cannabis). Furthermore, refrain from driving, operating machinery, or engaging in activities requiring alertness until you can do so safely. 

To prevent dizziness when taking this medication, exercise caution when transitioning from sitting or lying to standing up quickly. Rise gradually and stabilize yourself to minimize the risk of falling. 

The use of Procardia XL during pregnancy should only be considered if the potential benefits outweigh the potential risks.  

Nifedipine is excreted in breast milk. Therefore, Procardia XL should be used while breastfeeding only if the benefits outweigh the risks. 

Additional information

Generic name:

Nifedipine XL


ER Tablet, SA Tablet, Sustained Release Tablet


10mg, 20mg, 30mg, 60mg

Quantities Available:

60, 90, 100, 120

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Procardia XL (Nifedipine XL). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Procardia XL (Nifedipine XL).