Indications 

Tarceva is a prescription medicine indicated for the maintenance treatment of patients with non-small cell lung cancer (NSCLC) that has not progressed after four cycles of platinum-based first-line chemotherapy.  

This medication is also used to treat NSCLC that has advanced or spread after at least one prior chemotherapy regimen. 

Moreover, when combined with gemcitabine, Tarceva is a first-line treatment option for patients with locally advanced, unresectable, or metastatic pancreatic cancer. 

As a kinase inhibitor, Tarceva works by obstructing the function of an abnormal protein responsible for stimulating the multiplication of cancer cells. This mechanism aids in slowing down or halting the cancer cells from spreading. 

Uses and Dosage 

Before taking Tarceva and with every prescription refill, carefully review its medication guide and patient information leaflet. Should you have any questions, consult your healthcare provider or pharmacist. 

The dosage of this medication is individualized according to the patient’s medical condition, treatment response, and concurrent medications. 

Typically, Tarceva is taken once daily on an empty stomach, either an hour before or two hours after eating. 

To achieve optimal results, take this medication exactly as directed around the same times each day.  

Refrain from altering the prescribed dosage and duration of intake of this medication. Doing so will not accelerate improvement but will elevate the possibility of severe side effects. 

Side Effects 

Listed below are the potential adverse effects of Tarceva. Tell your doctor promptly if any of them last or worsen. 

Common Side Effects 

• Nausea, vomiting, diarrhea, appetite loss 
• Cough, breathing difficulties 
• Rash 
• A sensation of weakness or fatigue 

Serious Side Effects 

• Sudden chest pain, wheezing, dry cough, breathlessness 
• Intense abdominal pain, high fever, chills, coughing up blood 
• Persistent severe nausea, vomiting, or diarrhea 
• Eye discomfort, vision issues 
• Symptoms resembling a heart attack: 
  • Chest pressure 
  • Pain extending to the jaw or shoulder 
  • Nausea 
  • Sweating 
• Indicators of a stroke: 
  • Sudden weakness or numbness (especially on one side) 
  • Sudden severe headache 
  • Slurred speech 
  • Vision or balance problems 
• Kidney or liver complications: 
  • Little or no urination 
  • Swelling 
  • Rapid weight gain (particularly in the face and midsection) 
  • Nausea 
  • Vomiting 
  • Dark urine 
  • Yellowing of the skin or eyes 

Stop taking Tarceva and call your doctor immediately if any of the serious side effects are experienced. 

Seek immediate medical assistance if you exhibit indications of a severe skin reaction such as: 

• Fever 
• Sore throat 
• Burning eyes 
• Skin pain 
• Red or purple skin rash with blistering and peeling 

Allergic Reactions 

Although rare, a severe allergic reaction to Tarceva may occur. Promptly seek medical help in case of any signs of an allergic reaction, such as: 

• Hives 
• Difficulty breathing 
• Swelling of the face or throat 

Not all side effects of Tarceva are included in this list. Report any unmentioned symptoms to your doctor. 

Cautions 

Before starting treatment with Tarceva, inform your doctor if you have any known allergies, particularly to erlotinib or other medications. 

Consult your pharmacist for further information about Tarceva, as it may contain inactive components that may trigger allergic reactions or other complications. 

To ensure Tarceva is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Liver disease 
• Kidney disease 
• Gastrointestinal issues (like ulcers or diverticulosis) 

Notify all healthcare providers of any current or recently started or stopped medications, including prescription and over-the-counter drugs, vitamins, and herbal supplements, to reduce the possibility of drug interaction with Tarceva. 

Some products that may interact withTarceva are: 

• Medications reducing stomach acid (e.g., proton pump inhibitors like omeprazole) 
• Other medicines with bleeding/bruising potential (including antiplatelet drugs like clopidogrel, NSAIDs like ibuprofen/naproxen, and anticoagulants like warfarin/dabigatran) 

Antacids and H2 blockers, like ranitidine, can hinder the effectiveness of Tarceva. Seek guidance from your healthcare provider or pharmacist on the proper usage of these medications in conjunction with Tarceva. 

Taking Tarceva with aspirin can heighten the bleeding risk. Nonetheless, if your doctor has advised low-dose aspirin (typically 81-162 milligrams daily) for heart attack or stroke prevention, follow that guidance unless advised otherwise.  

Grapefruit can cause adverse reactions when taken with Tarceva. Refrain from consuming grapefruit products while taking this medication. 

Smoking cigarettes reduces Tarceva levels in the blood. Inform your doctor about your smoking habits or recent cessation. 

Sunlight exposure raises the likelihood of rash development during Tarceva treatment. Minimize unnecessary or extended sunlight exposure, wear protective clothing, including a hat and sunglasses, and apply sunscreen with SPF 15 or higher that contains zinc oxide or titanium dioxide. 

Tarceva carries the risk of triggering rashes and various skin complications. To protect the skin, use a gentle, alcohol-free moisturizer, cleanse with mild soap, and remove cosmetics with a mild cleanser. 

Do not take Tarceva during pregnancy, as it may pose risks to the fetus. Employ reliable birth control while on this medication and for at least one month after your final dose. 

Tarceva can be absorbed through the skin and lungs and might pose risks to an unborn baby. Pregnant women or those potentially becoming pregnant should avoid handling the medication or inhaling dust from the tablets. 

Abstain from breastfeeding while on Tarceva medication and for a period of at least 2 weeks following the last administered dose.