Trivastal (Piribedil) Medication


Trivastal (Piribedil)

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Drug Description


Trivastal is used in the treatment of Parkinson’s disease and age-related minor neurological disorders. It can be used as monotherapy or as an adjunctive treatment. It can help improve symptoms associated with Parkinson’s disease, such as motor impairments (e.g., tremors, stiffness, and slowness of movement) and non-motor symptoms (e.g., cognitive impairments, mood disorders). 

Trivastal, which contains the active ingredient piribedil, is a dopaminergic agonist. It works by stimulating dopamine receptors in the brain. Piribedil acts as a direct dopamine receptor agonist, specifically targeting D2 and D3 receptors. By binding to these receptors, it mimics the action of dopamine, a neurotransmitter that plays a crucial role in controlling movement and other functions in the brain. 

Use and Dosage 

Trivastal Sustained Release Tablet is typically taken orally, with or after meals, to minimize the potential for gastrointestinal side effects. Swallow the tablet whole, without crushing or chewing them, as they are designed to release the medication slowly over time. 

The initial recommended dosage of Trivastal Sustained Release Tablet is often one tablet (50 mg) daily during the first week. The dosage should be gradually increased under the guidance of a healthcare professional to find the optimal dose that effectively manages symptoms while minimizing side effects. The total daily dosage of the drug can range from 150 mg to 250 mg, divided into 3 to 5 administrations per day. However, the specific dosage and frequency will depend on the individual’s condition and should be determined by a healthcare professional.  

Do not abruptly stop the Tablet without consulting a healthcare professional, as sudden discontinuation of dopamine agents may lead to withdrawal symptoms. If a decision is made to discontinue Trivastal, the healthcare professional will provide guidance on a gradual dose reduction schedule. 

Follow the prescribed dosage and schedule and do not exceed the recommended dose unless instructed by a healthcare professional. 

Side Effects 

Common Side Effects 

  • Feeling of discomfort 
  • Headache 
  • Sleepiness 
  • Vomiting 

Serious Side Effects 

  • Agitation and anxiety 
  • Compulsive behavior 
  • Confusion 
  • Dizziness 
  • Flatulence 
  • Increased libido 
  • Low blood pressure 
  • Nausea and Vomiting 
  • Severe skin rash and hives 
  • Sleeplessness 
  • Sudden sleeping fits 


  • Interaction with Other Medications: Piribedil may interact with certain medications. Inform your healthcare professional about all the medications you are taking, including prescription, over-the-counter, and herbal supplements, to avoid potential drug interactions. 
  • Driving and Operating Machinery: Piribedil may cause drowsiness, which can impair your ability to drive or operate heavy machinery. Use caution and avoid such activities until you know how the medication affects you. 
  • Pregnancy and Breastfeeding: The use of Trivastal during pregnancy or breastfeeding should be carefully evaluated. The potential benefits and risks should be discussed with a healthcare professional to make an informed decision. 
  • Individual Considerations: Piribedil dosing and usage may need to be adjusted based on individual factors such as age, overall health, and other medical conditions. Consultation with a healthcare professional is important to determine the appropriate dosage and usage instructions for each person. 
  • Hypotension: Trivastal may cause a drop in blood pressure, leading to symptoms such as dizziness or fainting. Individuals with low blood pressure or those taking blood pressure-lowering medications should use Piribedil with caution and under the guidance of a healthcare professional. 
  • Impulse Control Disorders: Like other dopamine agonists, Trivastal has been associated with impulse control disorders such as compulsive gambling, binge eating, and hypersexuality. Individuals and their caregivers should be vigilant for any changes in behavior or urges and report them to a healthcare professional. 
  • Mental Health Effects: Piribedil may cause or exacerbate psychiatric symptoms such as hallucinations, confusion, agitation, or psychosis. Individuals with a history of mental health disorders should be closely monitored while taking Trivastal. 
  • Renal and Hepatic Impairment: Piribedil should be used with caution in individuals with renal or hepatic impairment. Dose adjustments may be necessary based on the severity of impairment.  
  • Cardiovascular Disease: Trivastal should be used with caution in individuals with cardiovascular disease, as it may have effects on heart function. Close monitoring and appropriate dose adjustments may be required. 
  • Surgery: If you are scheduled for surgery, inform your healthcare professional that you are taking Trivastal, as it may interact with certain anesthetics or other medications used during the procedure. 
  • Allergic Reactions: Some individuals may be allergic to Trivastal or its components. If you experience signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, seek immediate medical attention.  

Additional information

Generic name:



Sustained Release Tablet



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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Trivastal (Piribedil). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Trivastal (Piribedil).