Depakene Oral Solution (Valproic Acid) Medication


Depakene Oral Solution (Valproic Acid)

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Table of contents:

Drug Description


Depakene Oral Solution is prescribed either as a monotherapy or in conjunction with other medications for the management of: 

  • Complex partial seizures in adults and children aged ten and above. 
  • Simple and complex absence seizures, whether they occur alone or alongside other seizure types. 

Categorized as an anticonvulsant, Depakene functions by reinstating balance among certain natural substances (neurotransmitters) in the brain. 

Uses and Dosage 

Before taking Depakene Oral Solution, thoroughly review the accompanying medication guide and patient information leaflet. If you have any inquiries or need additional information, consult your doctor or pharmacist for guidance. 

The recommended dosage of this medication is individualized and may depend on factors such as age, body weight, medical condition, treatment response, and concurrent medication use. 

Depakene Oral Solution is typically taken two or more times daily as prescribed by the doctor. It may be taken with food if stomach upset occurs. 

When measuring the solution, use a dedicated dose-measuring spoon or a medicine cup to ensure precise dosage intake. 

Avoid combining Depakene Oral Solution with carbonated beverages, as this may lead to mouth and throat irritation. 

For optimal results, take this medication exactly as directed at the same time each day. Refrain from altering the prescribed dosage and frequency of intake without your doctor’s recommendations. 

Do not discontinue Depakene Oral Solution abruptly, even if you feel well. Abrupt cessation can lead to a severe, life-threatening seizure condition. Adhere to your doctor’s guidance regarding gradual dose reduction. 

Side Effects 

The potential adverse effects of Depakene Oral Solution are outlined below. Should any of these symptoms last or worsen, promptly inform your doctor. 

Common Side Effects 

  • Nausea, vomiting, stomach pain, diarrhea 
  • Dizziness, drowsiness, weakness 
  • Headache 
  • Tremors, issues with coordination and walking 
  • Blurred vision, double vision 
  • Hair loss 
  • Alterations in appetite and weight gain 

Serious Side Effects 

  • Confusion, fatigue, cold sensation, vomiting, alterations in mental state 
  • Easier bruising, unusual bleeding (nose, mouth, or gums), purple or red pinpoint spots under the skin 
  • Severe drowsiness 
  • Worsening of seizures 
  • Indication of liver or pancreas problems, such as: 
    • Loss of appetite 
    • Upper stomach pain (that may spread to your back) 
    • Ongoing nausea or vomiting 
    • Dark urine, 
    • Swelling in the face 
    • Jaundice (yellowing of the skin or eyes) 

If you experience any serious side effects, promptly contact your doctor.  

Inform your doctor of any emerging or deteriorating symptoms, including: 

  • Changes in mood or behavior 
  • Depression 
  • Anxiety 
  • Panic attacks 
  • Sleep disturbances 
  • Impulsivity 
  • Irritability 
  • Agitation 
  • Hostility 
  • Aggression 
  • Restlessness 
  • Hyperactivity (mentally or physically) 
  • Thoughts of self-harm or suicide 

Drug Reactions 

Seek immediate medical attention if you experience a severe drug reaction with widespread effects on your body, such as symptoms like: 

  • Skin rash 
  • Fever 
  • Swollen glands 
  • Muscle aches 
  • Pronounced weakness 
  • Unusual bruising 
  • Yellowing of the skin or eyes 

Skin Reactions 

Promptly seek emergency medical aid if you exhibit indications of a severe skin reaction such as: 

  •  Fever 
  • Sore throat 
  • Burning eyes 
  • Skin pain 
  • Presence of a red or purple rash with blistering and peeling 

Allergic Reactions 

In rare cases, Depakene Oral Solution may trigger a severe allergic response. Promptly seek medical attention if you observe any indications of such a reaction, including: 

  • Swelling (especially in the face, tongue, or throat) 
  • Hives 
  • Breathing difficulties 

This list does not cover all side effects of Depakene Oral Solution. Should you notice any unlisted effects, notify your doctor. 


Before starting treatment with Depakene Oral Solution, inform your doctor if you have any known allergies, particularly to valproic acid, divalproex sodium, or any of the inactive ingredients in this oral solution. 

Disclose to your doctor your medical background before taking Depakene Oral Solution to determine its suitability for your condition, particularly if you have a history of: 

  • Liver disease 
  • Pancreatitis 
  • Specific metabolic disorders (urea cycle disorders, Alpers-Huttenlocher syndrome) 
  • Alcohol abuse 
  • Bleeding problems 
  • Dementia 
  • Kidney disease 
  • Dehydration 
  • Malnutrition 

Depakene Oral Solution may interact with various products, including: 

  • Specific antidepressants (amitriptyline, nortriptyline, phenelzine) 
  • Certain antibiotics (carbapenems such as imipenem) 
  • Irinotecan 
  • Mefloquine 
  • Orlistat 
  • Other seizure medications (e.g., ethosuximide, lamotrigine, rufinamide, topiramate) 
  • Vorinostat 
  • Warfarin 
  • Zidovudine 

To minimize the risk of drug interaction with Depakene Oral Solution, inform all your healthcare providers of your complete medication regimen, including prescriptions, over-the-counter products, vitamins, and herbal supplements. 

Continue taking low-dose aspirin, as your doctor directs, for specific medical purposes like preventing heart attacks or strokes (typically 81-162 milligrams daily). Seek advice from your doctor or pharmacist if you are using aspirin for any other reason. 

Ensure to review all the labels of your medications, including allergy or cough-and-cold products, as they may contain drowsiness-inducing ingredients. Seek guidance from your pharmacist regarding the safe use of such products, particularly if you are taking: 

  • Alcohol 
  • Marijuana (cannabis)  
  • Antihistamines (e.g., cetirizine, diphenhydramine)  
  • Drugs for sleep or anxiety (e.g., alprazolam, zolpidem) 
  • Muscle relaxants (e.g., carisoprodol, cyclobenzaprine) 
  • Opioid pain relievers (e.g., codeine, hydrocodone) 

The use of Depakene Oral Solution may disrupt certain lab tests, including urine ketones. Communicate this information to lab personnel and your doctors beforehand. 

Depakene Oral Solution can cause drowsiness. Refrain from driving or operating machinery until you have assessed its impact on your alertness. 

Depakene Oral Solution has the potential to induce profound drowsiness, resulting in decreased food and beverage consumption, particularly among older individuals. Notify your doctor if you notice any changes in your normal eating or drinking patterns. 

Consult with your doctor before initiating or discontinuing the use of Depakene Oral Solution while pregnant. The potential risks include harm to the unborn child or the occurrence of congenital disabilities. However, experiencing a seizure during pregnancy can be detrimental to both the mother and the baby. 

If you are not currently pregnant, use a reliable birth control methods while taking Depakene Oral Solution to avoid pregnancy. Inform your doctor if you initiate or discontinue the use of estrogen-based hormonal contraceptives such as birth control pills, injections, implants, skin patches, or vaginal rings. The interaction may compromise valproic acid’s seizure-preventing capabilities with estrogen. 

Consult your doctor regarding potential risks associated with breastfeeding while taking Depakene Oral Solution. 

Additional information

Generic name:

Valproic Acid





Quantities Available:

240mL, 450mL, 480mL

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Depakene Oral Solution (Valproic Acid). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Depakene Oral Solution (Valproic Acid).