Drixoral Decongestant Nasal Spray (Oxymetazoline Hydrochloride - otc) Medication


Drixoral Decongestant Nasal Spray (Oxymetazoline Hydrochloride - otc)

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Drug Description


Drixoral Decongestant Nasal Spray is used to provide temporary relief from nasal congestion stemming from a range of conditions, such as the common cold, sinusitis, hay fever, and allergies. 

As a decongestant, Drixoral works by constricting nasal blood vessels, thereby diminishing inflammation and congestion. 

Uses and Dosage 

Before using Drixoral Decongestant Nasal Spray, and every time you get a refill, thoroughly review the product package and accompanying patient information leaflet. If you have any inquiries or need additional information, consult a doctor or pharmacist. 

Drixoral Decongestant Nasal Spray is indicated for nasal use only and should not be ingested. 

Typically, 2 or 3 sprays of Drixoral are administered in each nostril, with a minimum interval of 10 to 12 hours between doses. Refrain from surpassing two doses within 24 hours. 

To properly use this nasal spray: 

  1. Clear your nostrils by gently blowing your nose. 
  2. Close one nostril with your finger. 
  3. Maintain an upright head position and insert the spray tip into the open nostril. 
  4. Spray the medication while inhaling through your nose. 
    • Sniff forcefully to ensure the medication reaches deep into your nasal passages. 
    • Be cautious not to spray the medication into your eyes or onto the nasal septum. 
  5. Repeat steps 2-4 for the other nostril if necessary. 
  6. After use, wipe the nozzle clean and securely replace the cap. 

To achieve the best outcome, follow the precise instructions provided in the Drixoral Decongestant Nasal Spray packaging or use as your doctor instructed. 

Do not use this medication more often, use more sprays, or use longer than directed; doing so may increase the risk of side effects. 

Moreover, refrain from using this medication for more than 3 days to prevent rebound congestion, characterized by prolonged nasal redness, swelling, and increased runny nose. If such symptoms occur, discontinue use, and seek advice from your healthcare provider or pharmacist. 

Side Effects 

Listed below are the potential side effects of Drixoral Decongestant Nasal Spray. Tell your doctor right away if any of these symptoms persist or worsen. 

Common Side Effects 

  • Slight burning or stinging sensation on the nose 
  • Sneezing 
  • Runny nose 

Serious side effects 

  • Continued or deteriorating symptoms 
  • Intense nasal burning or stinging following nasal spray usage 
  • Chest discomfort, rapid or irregular heartbeat 
  • Severe headache, ringing in ears, unease, disorientation, or breathlessness 

Stop using Drixoral Decongestant Nasal Spray and contact your doctor immediately if any serious side effects occur. 

Allergic Reactions 

In rare cases, Drixoral Decongestant Nasal Spray may trigger a severe allergic reaction. Promptly seek medical assistance upon observing any indications of a severe allergic response, including: 

  • Face, lips, tongue, or throat swelling 
  • Hives 
  • Trouble in breathing 

This list does not cover all side effects of Drixoral Decongestant Nasal Spray. If you experience any other effects, contact your doctor or pharmacist. 


Before starting treatment with Drixoral Decongestant Nasal Spray, talk to your doctor if you have any known allergies, particularly to oxymetazoline or any of the non-active ingredients of this nasal spray. 

Consult your doctor to assess the appropriateness of Drixoral Decongestant Nasal Spray for your condition, particularly if you have a history of: 

  • Heart or blood vessel disease 
  • Hyperthyroidism (overactive thyroid) 
  • Diabetes 
  • Hypertension (high blood pressure) 
  • Difficulty urinating (due to enlarged prostate) 

Consult your doctor or pharmacist to determine the safety of using Drixoral Decongestant Nasal Spray if you are currently taking any of the following medications: 

  • Antidepressant (e.g., amitriptyline, clomipramine, desipramine, doxepin, imipramine, or nortriptyline) 
  • Ergot medicine (e.g., ergotamine, dihydroergotamine, ergonovine, or methylergonovine) 
  • MAO inhibitors (e.g., isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine) 

Other medications not listed here may interact with Drixoral Decongestant Nasal Spray. To lower the risk of such interactions, talk to your doctor or pharmacist if you also take other prescription and nonprescription medicines, vitamins, and herbal supplements. 

Refrain from sharing your Drixoral Decongestant Nasal Spray with others, as this can potentially transmit infections, even if they exhibit similar symptoms to yours. 

The impact of Drixoral Decongestant Nasal Spray on the development of an unborn baby is uncertain. Notify your healthcare provider if you are pregnant or have plans to conceive while utilizing this medication. 

Breastfeeding mothers should consult their healthcare provider before using Drixoral Decongestant Nasal Spray, as the potential transfer of oxymetazoline into breast milk and its impact on nursing infants remains uncertain.  

Additional information

Generic name:

Oxymetazoline Hydrochloride – otc


Nasal Spray



Quantities Available:

30mL, 60mL

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Drixoral Decongestant Nasal Spray (Oxymetazoline Hydrochloride - otc). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Drixoral Decongestant Nasal Spray (Oxymetazoline Hydrochloride - otc).