Indications 

Esbriet is a proven pharmaceutical treatment for idiopathic pulmonary fibrosis (IPF), a respiratory condition characterized by the formation of fibrous tissue in the lungs. This fibrous tissue gradually thickens and stiffens, impairing lung function and causing respiratory distress. The reduced oxygen supply to vital organs, such as the brain and heart, can result in various associated medical complications. While the exact cause of IPF is unknown, the disease is progressive and can be life-threatening. 

Note that Esbriet does not offer a curative approach for IPF. However, this pharmaceutical agent demonstrates the potential to decelerate the progression of the disease, thereby providing valuable therapeutic benefits. 

Uses and Dosage 

Pirfenidone is a pharmacological agent indicated for treating IPF, a specific lung disorder characterized by the formation of scar tissue and subsequent lung stiffness, leading to respiratory difficulties. Pirfenidone is known to mitigate the progression of IPF potentially, thus offering a therapeutic benefit. 

Various factors, including your medical condition, response to treatment, and concurrent medication usage, determine the appropriate dosage of pirfenidone. Inform your healthcare provider and pharmacist about all the products you are currently using, encompassing both prescription and nonprescription drugs and herbal products. 

This medication should be administered orally with food, following your doctor’s instructions, typically three times a day. Taking pirfenidone alongside a meal has been associated with potentially reducing dizziness and nausea. To minimize the risk of adverse effects, your doctor may recommend initiating and gradually increasing treatment with a low dose. Adhere diligently to your doctor’s instructions throughout treatment. 

Side Effects 

Common Side Effects

Common side effects of pirfenidone include:  

• Tiredness 
• Lack of energy 
• Loss of appetite 
• Weight loss 
• Changes in taste 
• Dizziness 
• Nausea 
• Upset stomach 
• Vomiting 
• Diarrhea 
• Heartburn 

Taking pirfenidone with food can mitigate these side effects. If these effects persist or worsen, inform your doctor or pharmacist. 

Severe Side Effects

Remember that your doctor has prescribed this medication because they have assessed that the potential benefits outweigh the risks of side effects. Many individuals who use this medication do not experience severe side effects. 

Although rare, pirfenidone may lead to severe liver disease. Seek immediate medical assistance if you encounter any symptoms of liver damage, such as:  

• Continuous nausea or vomiting 
• Loss of appetite 
• Stomach or abdominal pain 
• Yellowing of the eyes or skin 
• Dark urine 

Cautions 

Before initiating pirfenidone treatment, inform your doctor or pharmacist about any known allergies you have, including allergies to pirfenidone or other substances. This medication may contain inactive ingredients that trigger allergic reactions or other complications. For further information, consult your pharmacist. 

Before using this medication, disclose your medical history to your doctor or pharmacist, particularly if you have a history of liver disease or kidney disease (such as undergoing dialysis). 

Pirfenidone has the potential to induce dizziness. Consumption of alcohol or marijuana (cannabis) can intensify dizziness. Refrain from driving, operating machinery, or engaging in activities that require alertness until you are confident in your ability to do so safely. Limit the intake of alcoholic beverages. If you are using marijuana (cannabis), discuss it with your doctor.