Indications 

Fragmin specifically targets the clotting factors in the blood, and it does not dissolve existing blood clots. Fragmin Vial is primarily used for the prevention and treatment of blood clots in various clinical settings, such as during surgery, in patients with certain medical conditions, or in individuals at high risk of developing blood clots. 

Fragmin Vial contains the active ingredient dalteparin sodium, which is a type of heparin. Heparin is an anticoagulant, commonly known as a “blood thinner.” Fragmin works by inhibiting the clotting factors and enzymes involved in the blood clotting process. 

When Fragmin is injected subcutaneously, it helps to prevent the formation of blood clots by inhibiting the activity of thrombin, a key enzyme in the blood clotting cascade. By preventing the formation of blood clots, Fragmin helps to reduce the risk of conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and other clotting disorders. 

Use and Dosage 

Fragmin Vial is typically administered as a subcutaneous injection. The exact dosage and administration instructions should be provided by your healthcare professional. To use Fragmin Vial, follow the instructions provided by your healthcare professional. Here are general guidelines on how to use Fragmin Vial: 

1. Preparation: Wash your hands thoroughly with soap and water. Gather all the necessary supplies, including the Fragmin Vial, a syringe, and alcohol swabs. Ensure that the vial is properly stored and not expired. 
2. Inspect the vial: Check the vial for any visible signs of damage or contamination. Do not use the vial if it appears damaged or the solution looks discolored or contains particles. 
3. Clean the injection site: Choose an appropriate injection site, such as the abdomen. Clean the injection site with an alcohol swab and allow it to dry. 
4. Withdraw the medication: Remove the cap from the vial and clean the rubber stopper with an alcohol swab. Draw the appropriate dose of Fragmin into the syringe according to your healthcare professional’s instructions. Ensure that you have the correct dosage. 
5. Administer the injection: Pinch the cleaned injection site and insert the needle into the skin at a 45-degree angle. Slowly inject the medication subcutaneously. Be gentle and steady while injecting. 
6. Remove the needle: Once the medication is injected, withdraw the needle from the skin. Apply gentle pressure to the injection site with a cotton ball or sterile gauze. 
7. Dispose of the materials: Safely dispose of the used syringe and needle in a sharps container. Do not recap the needle. 

Note that these are general guidelines, and specific instructions may vary depending on your healthcare provider’s recommendations and the instructions provided with the medication. Always consult your healthcare professional for detailed instructions on using Fragmin Vial. 

Side Effects 

Common Side Effects  

• Bleeding 
• Bruising 
• Chest pain 
• Chills 
• Dizziness 
• Fainting, or swelling in your hands or feet 
• Fever 
• Headache 
• Injection site reactions (pain, redness, bruising, swelling) 
• Itching 
• Nausea 
• Rapid breathing 
• Rash 
• Shortness of breath 
• Unusual tiredness or weakness 
• Vomiting 
• Weakness 

Serious Side Effects 

• Easy bruising or bleeding 
• Pain, redness, irritation, bruising, or swelling where the medicine was injected  
• Unusual or prolonged bleeding  
• Unusual or easy bruising  
• Purple or red pinpoints under your skin 
• Dark urine  
• Black or bloody stools  
• Severe headache  
• Confusion  
• Trouble concentrating 
• Vision changes  
• Unusual dizziness  
• Pale skin 
• Shortness of breath 
• Trouble breathing 
• Rapid heart rate 
• Lightheartedness 
• Fainting  
• Coughing up blood or vomit that looks like coffee grounds 
• Loss of movement in any part of your body 
• Problems with speech vision or balance  
• Seizures 
• Sudden weakness 
• Numbness, tingling, or muscle weakness (especially in your legs and feet 

Cautions 

• Benzyl Alcohol Sensitivity: Fragmin Vial contains benzyl alcohol as a preservative. Serious and fatal adverse reactions, known as gasping syndrome, can occur in neonates and low-birth weight infants treated with medications containing benzyl alcohol. The minimum amount of benzyl alcohol at which serious adverse reactions may occur is not known. Pregnant women should use caution when administering Fragmin preserved with benzyl alcohol, and preservative-free formulations should be used where possible. 
• Spinal/Epidural Hematomas: Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins (LMWH) like Fragmin. Special caution should be taken in patients undergoing spinal or epidural procedures, as they are at a higher risk of bleeding problems around the spine when already on Fragmin. 
• Bleeding Risk: Fragmin is an anticoagulant, and its use may increase the risk of bleeding. People using Fragmin may bleed more easily, and caution should be exercised in patients with a history of bleeding disorders, active bleeding, or undergoing invasive procedures. 
• Thrombocytopenia: Fragmin Vial may cause a decrease in platelet count (thrombocytopenia), which can increase the risk of bleeding. Close monitoring of platelet count is recommended, especially in patients with a history of thrombocytopenia or heparin-induced thrombocytopenia. 
• Renal Impairment: Fragmin Vial is primarily eliminated by the kidneys, so caution should be exercised in patients with renal impairment. Dose adjustment may be necessary based on the patient’s renal function. 
• Hepatic Impairment: Fragmin Vial is metabolized in the liver, so caution should be exercised in patients with hepatic impairment. Dose adjustment may be necessary based on the patient’s liver function. 
• Hypersensitivity Reactions: Fragmin Vial can cause allergic reactions in some individuals. Patients with a known hypersensitivity to Fragmin or any of its components should avoid its use. 
• Pregnancy and Breastfeeding: Fragmin Vial should be used with caution during pregnancy and breastfeeding. The potential benefits and risks should be evaluated by a healthcare professional before initiating treatment. 
• Interactions with Other Medications: Fragmin Vial may interact with other medications, including other anticoagulants, antiplatelet drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), and certain antibiotics.