Lioresal (Baclofen) Medication


Lioresal (Baclofen)

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Lioresal is a prescribed medication for managing pain and spasticity (muscle stiffness and tightness) associated with multiple sclerosis, spinal cord injuries, or other spinal cord disorders. 

Classified as a skeletal muscle relaxant, Lioresal targets spinal cord nerves to reduce the occurrence and intensity of muscle spasms in patients with specific spinal cord conditions. Furthermore, it alleviates pain and enhances muscle mobility. 

Uses and Dosage 

Before taking Lioresal and with each prescription refill, thoroughly review its medication guide and patient information leaflet. Talk to your doctor or pharmacist about any queries or concerns. 

Lioresal dosage is individualized according to the patient’s medical condition and response to the treatment. It is usually taken three times a day as prescribed by the doctor, without regard to food intake.  

To mitigate potential side effects, healthcare professionals may initially prescribe a low dose and gradually titrate it. Adhere closely to the instructions provided by your doctor. 

Keep taking Lioresal even if you are feeling well. Ceasing intake without consulting your doctor, particularly after prolonged use of high doses, can lead to seizures, fever, confusion, muscle stiffness, or hallucinations. Your doctor will recommend a gradual reduction in dosage. 

Side Effects 

Listed below are the potential adverse effects of Lioresal. Promptly inform your doctor if any of these symptoms last or worsen. 

Common Side Effects 

  • Drowsiness 
  • Dizziness 
  • Weakness 
  • Tiredness 

Serious Side Effects 

  • Severe drowsiness 
  • Breathing problems 
  • Confusion 
  • Hallucinations 
  • Muscle weakness 
  • Itching, tingling, or twitching in hands, arms, feet, or legs 
  • Fever 

Call your doctor right away if you experience any of the severe side effects listed above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Lioresal may occur. Get medical attention immediately if you experience symptoms such as: 

  • Rash 
  • Itching 
  • Swelling, particularly on the face, throat, or tongue  
  • Severe dizziness 
  • Difficulty breathing 

This list does not contain all the potential side effects of Lioresal. If any unlisted effects occur, inform your physician promptly. 


Before starting treatment with Lioresal, inform your doctor and pharmacist if you have any known hypersensitivities, especially to baclofen, other medications, or any ingredients present in Lioresal tablets. 

To ensure Lioresal is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Mental illness or psychosis 
  • Epilepsy or other seizure disorder 
  • Problems with balance 
  • Cerebral palsy 
  • Parkinson’s disease 
  • Schizophrenia or a confused state 
  • High blood pressure or fast heart rate 
  • Rheumatic disease 
  • Stroke or blood clot 
  • Kidney disease 

To minimize the potential for drug interactions with Lioresal, inform all healthcare providers of your current use of prescription and non-prescription drugs, dietary supplements, and herbal products. 

Inform your physician or pharmacist of any other substances you may be using that have sedative effects, including: 

  • Oopioid analgesics or cough suppressants (e.g., codeine, hydrocodone) 
  • Alcohol 
  • Marijuana (cannabis) 
  • Sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem) 
  • Other muscle relaxants (e.g., carisoprodol, cyclobenzaprine) 
  • Antihistamines (e.g., cetirizine, diphenhydramine) 

Ensure to review the labels of all your medications, including allergy or cough-and-cold products, as they may contain drowsiness-inducing components. Consult with your pharmacist to ensure the safe usage of these products. 

Lioresal is not approved for treating skeletal muscle spasms caused by rheumatic disorders.  

The effectiveness of Lioresal in stroke, cerebral palsy, and Parkinson’s disease has not been established, and thus, it is not recommended for these conditions. 

Avoid taking Lioresal when muscle tone is necessary for safe balance and movement in specific activities. This medication can cause drowsiness, so refrain from driving or operating heavy machinery until you understand its effects on you. 

Lioresal should be used during pregnancy only if necessary. Consult with your doctor regarding the potential risks and benefits. 

Infants born to mothers who took Lioresal while pregnant may experience withdrawal symptoms like seizures or tremors. If you observe these signs in your newborn, inform the doctor immediately. 

Prior to breastfeeding, seek medical advice as baclofen can be transmitted through breast milk. 

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Lioresal (Baclofen). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Lioresal (Baclofen).