Zanaflex (Tizanidine) Medication


Zanaflex (Tizanidine)

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Zanaflex is a prescription medication indicated for the management of muscle stiffness or spasticity related to neurological conditions like Cerebral palsy. Zanaflex is classified as a Central Alpha-2-Adrenergic Agonist and may be prescribed as a monotherapy or adjunctive therapy. The safety and efficacy of Zanaflex in pediatric patients have not been established, and further research is warranted in this regard. 

Zanaflex is a muscle relaxant with a short duration of action. Its mechanism of action involves the inhibition of nerve impulses that transmit pain sensations to the brain. 

Uses and Dosage 

Zanaflex is generally administered up to thrice daily, with a recommended interval of 6 to 8 hours between doses. do not exceed three doses, equivalent to 36mg, within a 24-hour duration, as excessive intake may result in liver damage. 

While Zanaflex can be taken with or without food, you should maintain consistency in administration mode. Alternating between taking tizanidine with or without food can decrease its effectiveness or lead to heightened side effects. 

Interchanging between Zanaflex capsules and tablets may cause changes in side effects or efficacy. Therefore, if any changes are made, inform a physician if any deviations in either side effects or therapeutic outcomes occur. 

As Zanaflex is a short-acting medication, its impact is most pronounced between 1 and 3 hours following intake. Accordingly, it should only be taken for activities requiring muscle spasm relief. 

Regular liver function tests are essential to monitor the potential adverse effects of Zanaflex on the liver. 

In the case of long-term usage, sudden cessation of Zanaflex may result in withdrawal symptoms such as dizziness, palpitations, tremors, and anxiety. Therefore, consult with a physician on the appropriate measures to safely discontinue this medication. 

Side Effects 

Common Side Effects

Common side effects associated with Zanaflex use may include:  

  • Dry mouth 
  • Drowsiness 
  • Dizziness 
  • Lightheadedness 
  • Constipation 
  • Weakness 
  • Fatigue 

If any of these symptoms persist or worsen, inform your doctor or pharmacist. 

To alleviate dry mouth, individuals may consider sucking on sugarless hard candy or ice chips, chewing sugarless gum, drinking water, or utilizing a saliva substitute. 

To minimize the likelihood of experiencing dizziness or lightheadedness, individuals are recommended to get up slowly when transitioning from a sitting or lying position. 

Severe Side Effects

Keep in mind that this medication is prescribed to you based on a physician’s judgment of the greater benefits relative to the potential risks. Many individuals use this medication without experiencing significant side effects. 

Individuals are advised to seek immediate medical attention in the event of any severe side effects such as:  

  • Fainting 
  • Mental or mood changes 
  • Irregular heartbeat 
  • Vision changes 

This is not an exhaustive list of possible side effects. If you observe any other symptoms not mentioned above, kindly contact your doctor or pharmacist for advice. 


Prior to taking tizanidine, inform your doctor or pharmacist if you have any allergies, including an allergy to tizanidine or any other substances in the medication. Inactive ingredients in the product may trigger an allergic reaction or other complications. speak to your pharmacist for further information. 

before using this medication, inform your doctor or pharmacist of your medical history, particularly if you have a history of low blood pressure, kidney disease, or liver disease. 

Before undergoing surgery, inform your doctor or dentist about all the products you are using, including prescription drugs, nonprescription drugs, and herbal products. 

Older adults may be more susceptible to the side effects of this medication, particularly dizziness, and drowsiness. These effects can increase the risk of falls. 

Additional information

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Zanaflex (Tizanidine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Zanaflex (Tizanidine).