Indications 

Oxytrol Patch is a transdermal medication prescribed to alleviate symptoms of overactive bladder, including urgency, frequency, and urge urinary incontinence. 

Classified as a muscarinic antagonist, Oxytrol Patch works by inducing relaxation in the muscles of the bladder. 

Uses and Dosage 

Before using Oxytrol Patch, and with each prescription refill, carefully review its medication guide and patient information leaflet. Consult your doctor or pharmacist if you have any questions or concerns. 

Oxytrol Patch is intended solely for dermal application and should not be ingested. 

Typically, Oxytrol Patch is administered on the clean, dry, and smooth (fold-free) abdomen, hip, or buttock skin twice a week (every 3 to 4 days).  

To avoid skin irritation, administer the new patch on a distinct skin region. Refrain from administering a patch on the same area for a week. 

Avoid applying the patch to your waistline area to prevent potential rubbing caused by tight clothing. 

Ensure the selected areas for application are not oily, damaged (such as cuts or scrapes), irritated (such as rashes), or affected by any other skin issues. 

Do not place Oxytrol Patch on skin areas recently treated with oils, lotions, or powders, as they can hinder the patch’s adherence to your skin. 

To properly use Oxytrol Patch, follow these steps: 

1. Open the protective pouch and take out the patch. 
2. Peel off the first piece of liner from the sticky side of the patch while leaving the second strip of liner attached. 
3. Press the patch firmly onto your skin, ensuring the sticky side faces down. Avoid touching the sticky side with your fingers. 
4. Bend the patch in half and use your fingertips to roll the remaining part onto your skin, allowing the second liner strip to detach. 
5. Press firmly on the patch’s surface to secure it tightly to your skin. 
6. When it is time to remove the patch, do it slowly and gently. Fold the patch in half with the sticky sides together and dispose of it safely, away from the reach of children and pets.  
7. Wash the area under the patch with mild soap and warm water to eliminate residue.  
   1. You can use baby oil or a medical adhesive removal pad to remove any stubborn residue that does not come off with soap and water.  
   2. Avoid using alcohol, nail polish remover, or other solvents. 
8. Immediately apply a new patch to a different area by following steps 1-5 again. 

Once Oxytrol Patch is applied, it should be worn continuously until it is time to replace it with a new one. If the patch becomes loose or falls off prematurely, attempt to reattach it by gently pressing it with your fingers. 

If reattachment is not possible, discard the patch and apply a new one to a different area. The replacement patch should be applied on the next scheduled patch change day. 

For optimal results, apply Oxytrol Patch on the same 2 days each week and mark the medication package calendar to remember.  

Adhere to the prescribed directions when using this patch and avoid applying it more frequently than instructed by your doctor. 

Your doctor will determine the duration of treatment with Oxytrol Patch and may occasionally discontinue medication to assess its necessity. 

Side Effects 

Listed below are the potential adverse effects of Oxytrol Patch. If any of them last or worsen, tell your doctor immediately. 

Common Side Effects 

• Redness, itching, or mild skin irritation at the patch site 
• Dizziness 
• Drowsiness 
• Dry mouth 
• Dry eyes 
• Blurred vision 
• Constipation 
• Diarrhea 
• Decreased urination 

Serious Side Effects 

• Little or no urination 
• Severe constipation 
• Confusion or hallucinations 
• Vomiting, severe heartburn, or upper stomach pain 
• Pain or burning sensation during urination 
• Symptoms of dehydration: 
  • Excessive thirst 
  • Feeling hot 
  • Inability to urinate 
  • Heavy sweating 
  • Hot and dry skin 

Stop using Oxytrol Patch and call your doctor at once if you experience any of the severe side effects above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Oxytrol Patch may occur. Seek immediate medical attention if you observe any of the following symptoms: 

• Hives 
• Difficult breathing 
• Swelling (face, lips, tongue, or throat) 

Not all side effects of Oxytrol Patch are included in this list. Inform your physician right away if any unlisted effects occur. 

Cautions 

Before starting treatment with Oxytrol Patch, inform your doctor of any known allergies, particularly to oxybutynin, other drugs, or any of the components of Oxytrol Patch. 

To ensure Oxytrol Patch is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Active internal bleeding 
• Stomach/intestinal blockage or slow movement (e.g., gastric retention, paralytic ileus) 
• Specific bladder problems (urinary retention, bladder outflow obstruction, stress incontinence) 
• Narrow-angle glaucoma 
• Muscle disease (myasthenia gravis) 
• Liver disease 
• High blood pressure 
• Heart problems (coronary artery disease, congestive heart failure, arrhythmias) 
• Stomach/intestinal disease (acid reflux, hiatal hernia, ulcerative colitis, intestinal atony) 
• Kidney disease 
• Loss of mental abilities (dementia) 
• Enlarged prostate 
• Overactive thyroid (hyperthyroidism) 
• Nervous system disorder (autonomic neuropathy) 
• Parkinson’s disease 

Notify all healthcare providers about any current or newly initiated or discontinued medications, including prescription and non-prescription drugs, vitamins, and herbal supplements, as they may interact with Oxytrol Patch. 

Drug interactions with Oxytrol Patch include: 

• Pramlintide 
• Medications that can irritate the esophagus/stomach, such as: 
  • Potassium tablets/capsules 
  • Oral bisphosphonates (including alendronate and etidronate) 

Ensure to review the labels of all your medications, including allergy or cough-and-cold products, as they may contain ingredients that can induce drowsiness, constipation, or blurred vision. Consult your pharmacist regarding the safe usage of such products. 

Be sure to inform your doctor or pharmacist if you are utilizing other drowsiness-inducing products, including: 

• Opioid pain or cough relievers (such as codeine, hydrocodone) 
• Alcohol 
• Marijuana (cannabis) 
• Sleep or anxiety medications (such as alprazolam, lorazepam, and zolpidem) 
• Muscle relaxants (such as carisoprodol, cyclobenzaprine) 
• Antihistamines (such as cetirizine, and diphenhydramine) 

Wearing the Oxytrol Patch during a magnetic resonance imaging (MRI) test may result in skin burning. Remove the patch before undergoing an MRI. 

The use of Oxytrol Patch can hinder the body’s ability to cool down in extreme heat. Avoid exposure to extreme heat and seek medical attention if experiencing symptoms of heat stroke such as fever, dizziness, upset stomach, headache, confusion, and fast pulse. 

The use of Oxytrol Patch during pregnancy is only recommended if the benefits outweigh the risks to both the patient and the fetus. Patients who become pregnant while using this patch should consult their physician. 

The excretion of oxybutynin in human milk is uncertain. Therefore, administering Oxytrol Patch to a nursing woman requires caution due to the possibility of drug excretion in human milk.