Lokelma (Sodium Zirconium Cyclosilicate) Medication


Lokelma (Sodium Zirconium Cyclosilicate)

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Drug Description


Lokelma is a prescription medicine used to treat hyperkalemia, a condition characterized by excessive potassium levels in the bloodstream. 

Lokelma is categorized as a potassium binder. It lowers and maintains potassium levels by binding and removing it from the digestive tract, thereby preventing its entry into the bloodstream during continuous treatment. 

Uses and Dosage 

Before taking Lokelma and every time you get a refill, carefully review its medication guide and patient information leaflet. If you have any questions or concerns, do not hesitate to seek advice from your doctor or pharmacist. 

Lokelma’s dosage is individualized based on the patient’s medical condition and response to the treatment. Regular blood tests may be required by the doctor to monitor the medication’s effectiveness. 

Lokelma is administered orally by mixing the powder packet with water, with or without food intake. If your healthcare provider has prescribed other oral medications, taking them either 2 hours before or after taking Lokelma as directed may be necessary. 

The initial treatment of this medication requires taking it three times a day for a maximum of 48 hours, followed by a maintenance dose of once daily or every other day. 

The steps for taking Lokelma are as follows:  

  1. Fill a glass with about 3 tablespoons of water or more desired. 
  2. Empty the entire packet(s) of Lokelma into the glass. 
  3. Stir well and drink immediately. 
  4. If powder remains, add water, stir, and drink immediately. 
  5. Repeat until no powder remains. 

To achieve optimal results, take Lokelma at the same time every day or every other day, based on your response to the medication. Patients undergoing dialysis should only take this medication on non-dialysis days. 

Adhere strictly to the instructions for taking Lokelma. Do not exceed or reduce the prescribed dosage or frequency of use directed by your doctor. 

Side Effects 

Although many individuals using Lokelma do not experience severe side effects, some common side effects may still occur. If any symptoms below persist or worsen, promptly inform your physician or pharmacist. 

Common Side Effects 

  • Edema  
  • A sudden increase in body weight 

Allergic Reactions 

Severe allergic reactions to Lokelma are infrequent; however, seek medical attention immediately if you experience any symptoms listed below. 

  • Rash 
  • Facial, throat, or tongue swelling or itching 
  • Breathing difficulties 
  • Severe dizziness 

The side effects of Lokelma listed here are not complete. Tell your doctor promptly if you experience any unlisted side effects that cause discomfort.  


Before starting treatment with Lokelma, inform your doctor and pharmacist of any allergies you have, including allergies to sodium zirconium cyclosilicate, other medications, or any ingredients in Lokelma powder. You can obtain a list of the ingredients from your pharmacist. 

Before taking Lokelma, disclose to your doctor your medical history, particularly of: 

  • Stomach or intestinal problems, such as constipation or blockages 
  • Conditions that may be affected by the salt in this medication, such as: 
    • Heart failure 
    • High blood pressure 
    • Swelling/edema 
  • Kidney problems 

Inform your doctor of all current and newly started or discontinued medications, including prescription and over-the-counter medicines, vitamins, and herbal products, as they may interact with Lokelma. 

Individuals undergoing dialysis may exhibit increased susceptibility to the impact of this medication, particularly during instances of illness, such as reduced food or beverage intake, diarrhea, etc. Kindly notify your physician promptly in the event of any such occurrence. 

Before undergoing an X-ray scan of your abdomen/stomach, inform the X-ray staff that you are taking Lokelma. 

Although Lokelma is not expected to be systemically absorbed following oral administration and cause fetal exposure, pregnant women should still consult their doctor before taking this medication. 

The transfer of sodium zirconium cyclosilicate into breast milk is improbable. However, it is advisable to seek the advice of a medical practitioner before nursing. 

Additional information

Generic name:

Sodium Zirconium Cyclosilicate


Powder for Oral Suspension



Quantities Available:

3 sachets, 30 sachets

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Lokelma (Sodium Zirconium Cyclosilicate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Lokelma (Sodium Zirconium Cyclosilicate).