Monovisc (Sodium Hyaluronate) Medication

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Drug Description


Monovisc is prescribed to treat knee pain in patients with osteoarthritis (OA) when other non-drug therapies or basic pain relievers like acetaminophen have not provided sufficient relief. 

Monovisc is a thick, sterile solution produced from purified hyaluronan derived from bacterial fermentation. It mimics the fluid naturally found around our joints, providing lubrication and cushioning, which helps alleviate joint pain and enhance the function of the knee joint affected by osteoarthritis. 

Uses and Dosage 

Monovisc comes in a single-use syringe and is administered through an injection directly into the knee joint by a healthcare professional. 

Typically, Monovisc is administered as a single dose, but in some cases, more than one injection may be required. If additional injections are necessary, they are usually spaced at least one week apart from the initial injection. 

Adhere closely to the guidelines provided by your physician. 

This medication is intended to provide pain relief for several months. If your symptoms do not improve or worsen, inform your doctor. 

Side Effects 

Listed below are the potential adverse effects of Monovisc. If any of them last or worsen, tell your doctor promptly. 

Common Side Effects 

  • Joint pain, stiffness, or swelling 
  • Itching, numbness, or tingling 
  • Headache or dizziness 
  • Back pain 
  • Swelling, pain, redness, or mild discomfort at the injection site 

Serious Side Effects 

  • Bleeding 
  • Increased knee pain 
  • Signs of infection (warmth, swelling, redness) around the knee 

Tell your doctor right away if any of the severe side effects above are experienced. 

Allergic Reactions 

Although rare, a severe allergic reaction to Monovisc may occur. Seek prompt medical assistance if you experience any of the following symptoms: 

  • Hives 
  • Troubled breathing 
  • Swelling (especially the face, lips, tongue, or throat) 

This list does not contain all the potential side effects of Monovisc. If any unlisted effects are observed, tell your doctor promptly. 


Before starting treatment with Monovisc, inform your doctor if you have any known hypersensitivities, especially to: 

  • Sodium hyaluronate 
  • Gram-positive bacteria proteins (ask your doctor if uncertain) 
  • Other medications 
  • Any ingredients present in Monovis solution 

To ensure Monovisc is safe for you, disclose to your physician your medical background. Monovisc treatment is contraindicated for individuals with: 

  • Bleeding or blood clotting disorder present (e.g., hemophilia) 
  • Infection in the knee or skin around the knee 

Inform all healthcare providers of your current and new medication usage, as Monovisc may interact with other drugs such as prescriptions, over-the-counter medicines, vitamins, and herbal products. 

Refrain from jogging, strenuous activity, high-impact sports (like tennis), weight-bearing activity, or standing for more than an hour at a time for a minimum of 48 hours following the administration of Monovisc. 

The potential effects of Monovisc on an unborn child are unknown. If you are pregnant or planning to become pregnant while using Monovisc, inform your doctor. 

The potential transfer of hyaluronan into breast milk and its impact on nursing infants is uncertain. Inform your physician if you are currently breastfeeding. 

Additional information

Generic name:

Sodium Hyaluronate




20mg/mL, 22mg/mL

Quantities Available:


Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Monovisc (Sodium Hyaluronate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Monovisc (Sodium Hyaluronate).