Indications 

Diclofenac is classified as a nonsteroidal anti-inflammatory drug (NSAID) and is prescribed to alleviate pain and inflammation associated with knee arthritis while enhancing joint mobility and flexibility. 

Uses and Dosage 

Before the initial usage of the pump, this is imperative to detach the cap and prepare the pump as directed by the manufacturer. 

Administer the prescribed medication to unsoiled, dry skin following the instructions of your medical practitioner, generally twice daily on the affected knee(s). Firmly push down on the pump head twice and dispense the medication into the palm of your hand. Spread the drug uniformly around the knee’s anterior, posterior, and lateral parts. If instructed by your doctor, repeat the process on the other knee. Allow the medication to dry for several minutes. Refrain from covering the treated knee with clothing until this is entirely dry. Avoid using sunscreen, insect repellent, lotion, or other topical products on the treated area until completely dry. 

Ensure to wash your hands before and after applying the medication. Prevent the medicines from contacting the eyes, nose, or mouth. Do not bathe or shower for at least 30 minutes after application. Do not apply the medication to open wounds or infected or damaged skin. Unless your doctor advises, avoid wrapping, bandaging, or using heat (such as a heating pad) to the treated region. 

Use the medication as directed by your doctor to obtain maximum benefit. Do not exceed the prescribed amount, increase the frequency of administration, or use it for longer than required. 

Side Effects 

If you experience the following symptoms while taking Pennsaid, seek immediate medical attention by calling your doctor or visiting the emergency department if you encounter: 

• Breathing difficulties 
• Or facial or throat swelling, which may indicate a severe allergic reaction 
• Chest pain 
• Shortness of breath 
• Weakness on one side of the body, slurred speech 
• Signs of blood clotting events  

If you experience any of the following: 

• Upper stomach pain 
• Upset stomach 
• Black or tarry stools 
• Vomiting of blood may indicate an ulcer 
• Bleeding or tearing in the esophagus, stomach, or intestine, especially if you take low-dose aspirin 

Liver problems, which can be indicated by: 

• Nausea 
• Fatigue 
• Weakness 
• Itching 
• Yellowing of the skin or eyes 
• Right upper abdomen tenderness 
• Flu-like symptoms, require prompt medical attention 
• Shortness of breath 
• Sudden weight gain or swelling in the arms, legs, hands, or feet  
• Rash 

Caution 

Pennsaid should not be used before or after heart bypass surgery. The use of diclofenac, the active ingredient in Pennsaid, can increase the risk of fatal heart attack or stroke, particularly in long-term use, high doses, or in people with heart disease.  

People who are allergic to diclofenac or have had asthma attacks or severe allergic reactions after taking aspirin or NSAIDs should not use Pennsaid. Patients with heart disease, high blood pressure, high cholesterol, diabetes, a history of heart attack, stroke, blood clots, stomach ulcers or bleeding, asthma, liver or kidney disease, or fluid retention should inform their doctor before using Pennsaid.  

Diclofenac can impact ovulation and may reduce the chances of getting pregnant. Pennsaid should not be used during the last 20 weeks of pregnancy, as it may cause severe heart or kidney problems in the unborn baby and complications during pregnancy. There is no information on whether diclofenac can pass into breast milk, and breastfeeding should be avoided while using Pennsaid.