Polytrim (Polymixin/trimethoprim) Medication

We don't sell this brand-version medication.
We don't sell this generic-version medication.
5 Star Excellence award from Shopper Approved for collecting at least 100 5 star reviews



Polytrim is an ophthalmic medication prescribed to treat bacterial infections, such as conjunctivitis (pinkeye; inflammation of the conjunctiva) or blepharoconjunctivitis (inflammation of the oil glands in the eyelids). 

Polytrim is composed of two antibiotics: polymyxin and trimethoprim. Polymyxin B acts by eradicating the bacteria, while trimethoprim hinders the bacteria’s growth. 

This medication exclusively treats bacterial eye infections and is ineffective against other eye infections. Misuse or unnecessary use of any antibiotic can result in reduced effectiveness. 

Uses and Dosage 

Before using Polytrim and with every prescription refill, carefully review its medication guide and patient information leaflet. If you have any uncertainties, consult your doctor or pharmacist for clarification. 

Polytrim is intended exclusively for ophthalmic use and should not be ingested or injected. 

Typically, Polytrim is administered as one drop in the affected eye(s) every three hours, with a maximum of six doses per day, for a duration of 7 to 10 days. 

To properly administer Polytrim, follow these steps: 

  1. Prior to applying the eye drops, wash your hands thoroughly.  
  2. Avoid contamination by not touching the dropper tip or allowing it to touch the eye or any other surface. 
  3. Tilt your head backward and gaze upward. 
  4. Pull down the lower eyelid gently using your index finger to create a small pouch. 
  5. Directly position the dropper above your eye and gently squeeze it, allowing a single drop to fall into the pouch. 
  6. Remove your index finger from the lower eyelid. 
  7. Close your eye and tilt your head downward as if looking at the floor. 
  8. Apply gentle pressure with a finger on the tear duct area for 2-3 minutes to prevent the medication from draining out. Avoid blinking or rubbing your eye during this time. 
  9. Repeat these steps if your prescribed dose requires more than one drop. 
  10. Repeat the procedure for the other eye if instructed to use the medication in both eyes. 
  11. Securely replace and tighten the cap on the dropper bottle after use. Do not wipe or rinse the dropper tip. 
  12. Wash your hands after administering the eye drops to remove any residue. 

For optimal results, use Polytrim exactly as directed at around the same time every day. Do alter the number of drops and frequency of use than prescribed by your doctor. 

Complete the full prescription of Polytrim, even if symptoms improve. Ceasing the medication prematurely could facilitate the continued growth of bacteria, potentially leading to a recurrence of the infection. 

Side Effects 

Listed below are the potential adverse effects of Polytrim. If any of them persist or worsen, promptly inform your healthcare provider.  

Common Side Effects 

  • Mild sensations of burning, stinging, or itching in the eyes 

Serious Side Effects 

  • Eye pain, swelling, redness, or severe discomfort 
  • Crusting or drainage (may indicate infection) 
  • Swelling or redness of the eyelids 
  • New or worsening symptoms 

Call your doctor promptly and ask for medical assistance if you experience any of the serious side effects above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Polytrim may occur. Seek prompt medical attention if any signs of a severe allergic reaction are observed, such as: 

  • Hives 
  • Difficulty breathing 
  • Swelling (face, lips, throat, or tongue) 

Not all side effects of Polytrim are included in this list. Inform your doctor immediately if any unlisted effects occur. 


Before starting treatment with Polytrim, inform your doctor of any known allergies, particularly to polymixin, trimethoprim, or other medications. 

Consult your pharmacist for further details, as Polytrim may contain inactive ingredients that can potentially trigger allergies or other complications. 

Disclose to your physician your medical background to ensure Polytrim is safe for you. 

Eye medications like Polytrim are generally not susceptible to interactions with other drugs. However, inform your doctor about all the medicines you are currently taking, including prescriptions, over-the-counter medications, vitamins, and herbal products, to lower the possible drug interactions. 

The use of Polytrim during pregnancy should be limited to situations where it is deemed necessary. Consult with your doctor to thoroughly assess the potential risks and benefits associated with its usage. 

The transfer of polymyxin or trimethoprim into breast milk is uncertain but is unlikely to cause harm to a nursing infant. Consult your doctor before breastfeeding while using this medication. 

Additional information

Generic name:



Eye drops



Quantities Available:


Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Polytrim (Polymixin/trimethoprim). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Polytrim (Polymixin/trimethoprim).