Indications 

NeoMercazole serves as a pharmacological intervention within the realm of anti-thyroid agents. Clinical tility encompasses a spectrum of indications, specifically in cases necessitating the reduction of thyroid function. These include the management of hyperthyroidism, the preparation of individuals undergoing thyroidectomy for hyperthyroidism, as well as adjunctive therapy preceding and following radio-iodine treatment. 

Uses and Dosage 

NeoMercazole is intended for oral administration exclusively. Initiation should be contingent upon the confirmation of hyperthyroidism through laboratory assessments. 

The initial dosage typically falls within the 20-60 mg range for adults. It should be adjusted in response to thyroid function measurements until the patient achieves a euthyroid state, thereby mitigating the potential for over-treatment and subsequent hypothyroidism. Subsequent therapeutic approaches may be pursued in one of two manners: 

• Maintenance Regimen: The final prescribed dose generally falls within 5-15 mg daily and may be taken as a daily dose. This therapeutic regimen should be sustained for at least six months and up to eighteen months. Monitor thyroid function serially and make appropriate dosage adjustments to maintain a euthyroid condition. 
• Blocking-Replacement Regimen: The dosage is retained at the initial level, i.e., 20-60 mg per day, concurrently with administering supplemental l-thyroxine at a dose of 50-150 mcg per day. This combined approach serves to prevent hypothyroidism. Therapy should continue for at least six months and up to eighteen months. 

Regarding the elderly population (65 or older), while there is no specific dosage regimen, exercise caution and adhere to contraindications and warnings due to reports indicating a potentially higher risk of a fatal outcome related to neutrophil dyscrasia. 

For children, the typical initial daily dosage is 15 mg per day. 

Side Effects 

Adverse reactions manifest predominantly within the initial eight weeks of the treatment course. Among the most commonly reported adverse effects are:  

• Nausea 
• Headaches 
• Arthralgia 
• Mild gastric discomfort 
• Skin rashes 
• Pruritus 

These adverse reactions typically follow a self-limiting course and often do not necessitate medication discontinuation. 

Cautions 

Here are some crucial guidelines to follow while taking Neo-Mercazole: 

• When starting any new medication, kindly inform your doctor and pharmacist that you are using Neo-Mercazole. 
• You must notify any other healthcare professionals, such as dentists or additional doctors, about your Neo-Mercazole regimen during their treatment. 
• If you become pregnant while using this medication, promptly inform your doctor. 
• If you have deviated from your prescribed medication regimen for any reason, communicate this to your doctor. Otherwise, your doctor may incorrectly assess the effectiveness and make unnecessary changes to your treatment. 
• Inform your doctor if the tablets need to manage your condition more effectively. 
• Neo-Mercazole should only be used as directed by your doctor and for the specific condition, it was prescribed for. Do not use it to address any other health concerns unless explicitly instructed by your doctor. 
• Refrain from sharing your medication with anyone else, even if they have a similar medical condition. 
• Ensure you have an adequate supply of medication to avoid running out over weekends or holidays.