Nexletol (Bempedoic) Medication

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Drug Description


Nexletol is a prescription medicine used along with proper diet and maximum statin therapy to help adults who require further reduction of “bad” cholesterol (low-density lipoprotein LDL-C) and have either heterozygous familial hypercholesterolemia (HeFH – an inherited condition leading to high LDL-C levels) or known cardiovascular disease. 

Classified as an adenosine triphosphate-citrate lyase (ACL) inhibitor, Nexletol functions by inhibiting the liver’s production of cholesterol. 

Uses and Dosage 

Before taking Nexletol and with each prescription refill, carefully review its medication guide and patient information leaflet. Seek advice from your doctor or pharmacist if you have any questions or uncertainties. 

Typically, Nexletol is taken once a day as prescribed by the doctor, without regard to food intake.  

For optimal results, take this medication regularly at the same time daily. Avoid taking more or less of it or taking it more frequently than prescribed by your doctor. 

Continue taking Nexletol, even if you do not experience any symptoms, as individuals with high cholesterol typically do not feel unwell. 

Side Effects 

Listed below are the potential adverse effects of Nexletol. Inform your doctor right away if any of them last or worsen. 

Common Side Effects 

  • Common cold, flu, or flu-like symptoms 
  • Back pain 
  • Stomach pain 
  • Increased liver enzymes 
  • Muscle spasms 
  • Shoulder, leg, or arm pain 
  • Anemia 
  • Bronchitis 

Serious Side Effects 

  • Toe or joint pain 
  • Difficulty urinating (e.g., due to enlarged prostate) 

Tell your doctor right away if you experience any of the serious side effects listed above. 

Nexletol may cause tendon damage. If joint/muscle/tendon pain or swelling occurs, cease exercising, rest, and seek medical assistance immediately. Those over 60 years of age, taking corticosteroids or fluoroquinolones, or with kidney or tendon problems are at higher risk for tendon issues. 

Allergic Reactions 

Although rare, a severe allergic reaction to Nexletol may occur. Seek medical assistance promptly if you notice any of the following symptoms: 

  • Rash 
  • Severe dizziness 
  • Itching or swelling (especially of the face, tongue, or throat) 
  • Trouble breathing  

Not all side effects of Nexletol are included in this list. In case of any unlisted effects, tell your doctor immediately. 


Before starting treatment with Nexletol, inform your doctor and pharmacist of any known allergies, particularly to bempedoic acid, other drugs, or any of the components of Nexletol tablets. 

To ensure Nexletol is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Liver disease 
  • Kidney disease 
  • Gout 
  • Tendon problems 

Inform your doctor and pharmacist of all prescription and non-prescription drugs, vitamins, and herbal supplements you are taking to lower the risk of drug interaction with Nexletol. 

The use of Nexletol during pregnancy is not recommended, as it may pose a risk to the unborn baby. If you become pregnant, promptly consult your doctor regarding the potential risks and benefits associated with this medication. 

The transfer of bempedoic acid into breast milk is currently unknown. A decision regarding the use of Nexletol or breastfeeding should be made in consultation with your healthcare provider. Both options should not be pursued simultaneously.

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Nexletol (Bempedoic). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Nexletol (Bempedoic).