Questran Powder (Cholestyramine) Medication


Questran Powder (Cholestyramine)

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Questran Powder is a prescribed medication used alongside diet to lower high levels of serum cholesterol in patients with primary hypercholesterolemia (elevated low-density lipoprotein (LDL) cholesterol) who do not achieve sufficient results through diet alone. 

Questran Powder is also indicated for alleviating itching linked to partial biliary obstruction. 

Categorized as a bile acid sequestrant, Questran Powder functions by eliminating bile acid from the body. It binds and merges with the bile acids in the intestine to create an insoluble complex that is expelled in the feces, removing them from circulation and reducing cholesterol levels. 

Uses and Dosage 

Before taking Questran Powder and with each prescription refill, carefully review its medication guide and patient information leaflet. For queries or uncertainties, seek guidance from your doctor or pharmacist. 

The dosage of Questran Powder is determined based on the patient’s medical condition and response to the treatment.  

To minimize the risk of side effects, your doctor may advise starting with a low dose and gradually increasing it. Adhere strictly to your doctor’s instructions. 

Questran Powder is supplied in individual dose packets and should be mixed with liquids or food. Typically, this medication is taken once or twice daily. 

To prepare this medication, follow these steps:  

  1. Mix the powder into 2 to 6 ounces of water, milk, heavy or pulpy fruit juices (e.g., orange juice), or any other beverage you choose. 
    • If using a carbonated beverage, add the powder slowly to a large glass to prevent excessive foaming. 
  2. Thoroughly stir the mixture until the powder is completely dissolved. 
  3. Drink the mixture immediately after stirring. 
    • Refrain from sipping the mixture slowly or holding it in your mouth for an extended period, as this medication may cause damage to the teeth. 
  4. To ensure you consume all the powder, rinse the drinking glass with more of the chosen beverage and drink it entirely. 

Questran Powder may also be combined with applesauce, crushed pineapple, pureed fruit, and soup. However, it should not be heated when added to hot foods. 

For enhanced taste and convenience, you can prepare daily doses the night before and store them in the refrigerator. 

To achieve the best outcomes, take this medication at a consistent time each day. Continue taking it even if you feel well, as most individuals with high cholesterol may not experience symptoms. 

Side Effects 

Listed below are the potential adverse effects of Questran Powder. If any of them persist or worsen, promptly inform your doctor. 

Common Side Effects 

  • Mild constipation or diarrhea 
  • Stomach pain, nausea, or loss of appetite 
  • Bloating or gas 
  • Irritation of the tongue 
  • Itching or irritation around the rectal area 

Serious Side Effects 

  • Ongoing or worsening constipation (more likely in older adults) 
  • Severe stomach pain 
  • Blood in urine 
  • Black, bloody, or tarry stools 
  • Easy bruising or unusual bleeding 

Inform your doctor right away if you experience any of the serious side effects mentioned above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Questran Powder may occur. Seek prompt medical assistance if you experience indications of an allergic reaction, such as: 

  • Rash 
  • Face, tongue, or throat swelling or itching  
  • Severe dizziness 
  • Trouble breathing 

Not all side effects of Questran Powder are included in this list. Inform your doctor promptly if any unlisted effects are observed. 


Before starting treatment with Questran Powder, inform your doctor if you have any known allergies, particularly to cholestyramine and other medications. 

Ask your pharmacist for more information, as Questran Powder may contain inactive ingredients that may cause allergic reactions or other complications. 

To ensure Questran Powder is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Constipation 
  • Hemorrhoids 
  • Kidney disease 

Inform all your healthcare providers of any current, newly started, or stopped medications, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements, to mitigate the risk of drug interaction with Questran Powder. 

Some of the products that may interact with this medication include:  

  • Blood thinners (e.g., warfarin) 
  • Mycophenolate 
  • Raloxifene 

Questran Powder can interfere with the absorption of other medications. Take other medicine as your doctor prescribes, typically at least 1 hour before or 4 to 6 hours after Questran.  

Due to the potential interference of this medication with nutrient absorption (e.g., folic acid, fat-soluble vitamins A, D, E, K), your doctor may advise taking a multivitamin supplement.  

Consult your doctor before using Questran Powder if you have phenylketonuria (PKU), as it may contain phenylalanine. 

Questran Powder should only be used during pregnancy if necessary since it can impact the absorption of specific nutrients. Consult with your doctor to evaluate the risks and benefits. 

Although cholestyramine is not expected to transfer into breast milk, consulting with your doctor before breastfeeding is recommended due to its potential impact on nutrient absorption. 

Additional information

Generic name:



Packet, Powder



Quantities Available:

30pk, 90pk, 378g

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Questran Powder (Cholestyramine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Questran Powder (Cholestyramine).